However injections are not suitable for everyone, especially if you have a fear of needles or reactions at injection sites. A doctor can help you decide which option is best for you based on your preferences, lifestyle and health goals. Studies suggest that both semaglutide tablets and injections can help with weight loss, but the injections tend to be more effective. On average, people taking semaglutide injections can lose around 10-15% of their body weight over about a year. For semaglutide tablets, the weight loss tends to be slightly lower, around 5-10% of body weight over the same period.